Article
ACVR1C/SMAD2 signaling promotes invasion and growth in retinoblastoma.
Oncogene - 1 Mar 2019
Asnaghi Laura, White David T, Key Nolan, Choi Joshua, Mahale Alka, Alkatan Hind, Edward Deepak P, Elkhamary Sahar M, Al-Mesfer Saleh, Maktabi Azza, Hurtado Christopher G, Lee Grace Y, Carcaboso Angel M, Mumm Jeff S, Safieh Leen Abu, Eberhart Charles G
Abstract excerpt
Retinoblastoma is the most common intraocular cancer in children. While the primary tumor can often be treated by local or systemic chemotherapy, metastatic dissemination is generally resistant to therapy and remains a leading cause of pediatric cancer death in much of the world. In order to identify new therapeutic targets in aggressive tumors, we sequenced RNA transcripts in five snap frozen retinoblastomas...
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