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Oncolytic Seneca Valley Virus: past perspectives and future directions

1 Sept 2016

Abstract excerpt

Seneca Valley Virus isolate 001 (SVV-001) is an oncolytic RNA virus of the Picornaviridae family. It is also the first picornavirus discovered of the novel genus Senecavirus. SVV-001 replicates through an RNA intermediate, bypassing a DNA phase, and is unable to integrate into the host genome. SVV-001 was originally discovered as a contaminant in the cell culture of fetal retinoblasts and has since been...

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PMID: 27660749
DOI: 10.2147/ov.s96915

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