Article
Relationship of EGFR mutations, expression, amplification, and polymorphisms to epidermal growth factor receptor inhibitors in the NCI60 cell lines.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Nov 2007
Liu Wanqing, Wu Xiaolin, Zhang Wei, Montenegro Raquel C, Fackenthal Donna Lee, Spitz Jared A, Huff Lyn Mickley, Innocenti Federico, Das Soma, Cook Edwin H, Cox Nancy J, Bates Susan E, Ratain Mark J
Abstract excerpt
PURPOSE: The mechanism of sensitivity and resistance to epidermal growth factor receptor (EGFR) inhibitors is incompletely understood, particularly in cancers other than non-small-cell lung cancer (NSCLC). To understand the variable response to this class of drugs, we used the NCI60 cancer cell lines. We aimed to determine if there are interactions between EGFR expression, mutations, polymorphisms, and gene...
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