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Article

Global profiling of EGFR gene mutation, amplification, regulation and tissue protein expression in unknown primary carcinomas: to target or not to target?

Clinical & experimental metastasis - 1 Jan 2007

Dova Leukothea, Pentheroudakis George, Georgiou Ioannis, Malamou-Mitsi Vassiliki, Vartholomatos George, Fountzilas George, Kolaitis Nikolaos, Kitsiou Evangelia, Pavlidis Nicholas

Abstract excerpt

INTRODUCTION: Epidermal growth factor receptor (EGFR) signalling contributes to malignant transformation and survival. We studied molecular predictors of benefit from EGFR-modulating therapies in patients with cancer of unknown primary (CUP). MATERIALS AND METHODS: Tumours from paraffin-embedded biopsies of 50 patients with CUP were stained for EGFR protein by immunohistochemistry. Polymerase chain reaction...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17390112
DOI: 10.1007/s10585-007-9055-0

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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