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Article

Clinical implication of centrosome amplification and expression of centrosomal functional genes in multiple myeloma

23 Mar 2013

Abstract excerpt

BACKGROUND: Multiple myeloma (MM) is a low proliferative tumor of postgerminal center plasma cell (PC). Centrosome amplification (CA) is supposed to be one of the mechanisms leading to chromosomal instability. Also, CA is associated with deregulation of cell cycle, mitosis, DNA repair and proliferation. The aim of our study was to evaluate the prognostic significance and possible role of CA in pathogenesis and...

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PMID: 23522059
DOI: 10.1186/1479-5876-11-77

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