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Article

Host genetic variation contributes to phenotypic diversity in myeloproliferative disorders.

Blood - 1 Mar 2008

Pardanani Animesh, Fridley Brooke L, Lasho Terra L, Gilliland D Gary, Tefferi Ayalew

Abstract excerpt

JAK2V617F is an acquired mutation associated with polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF). We tested the hypothesis that the paradox of a single disease allele associated with 3 distinctive clinical phenotypes could be explained in part by host-modifying influences. We screened for genetic variation within 4 candidate genes involved in JAK-STAT signaling, including...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18006699
DOI: 10.1182/blood-2007-06-095703

Genes

JAK2
EPOR
MPL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Host genetic variation contributes to phenotypic diversity in myeloproliferative disorders.PMID 18006699Read ↗

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JAK2V617F homozygosity drives a phenotypic switch in myeloproliferative neoplasms, but is insufficient to sustain disease.Semantic proximity Read ↗

The JAK2V617F mutation in polycythemia vera and other myeloproliferative disorders: one mutation for three diseases?Semantic proximity Read ↗

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