Article
The JAK2V617F mutation in polycythemia vera and other myeloproliferative disorders: one mutation for three diseases?
Hematology. American Society of Hematology. Education Program - 1 Jan 2008
James Chloé
Abstract excerpt
The discovery of the JAK2V617F mutation has made the diagnosis of polycythemia vera (PV) much easier, but the pathogenesis of PV is still incompletely understood. In particular, it is not yet elucidated how a single mutation can be found in multiple myeloproliferative disorders (MPD) and myelodysplastic syndromes with ring sideroblasts and whether the sole JAK2V617F is sufficient to induce a MPD in humans....
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