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Article

Accumulation of DNA Damage in Hematopoietic Stem and Progenitor Cells during Human Aging

7 Mar 2011

Abstract excerpt

BACKGROUND: Accumulation of DNA damage leading to adult stem cell exhaustion has been proposed to be a principal mechanism of aging. Here we tested this hypothesis in healthy individuals of different ages by examining unrepaired DNA double-strand breaks (DSBs) in hematopoietic stem/progenitor cells matured in their physiological microenvironment. METHODOLOGY/PRINCIPAL FINDINGS: To asses DNA damage accumulation...

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PMID: 21408175
DOI: 10.1371/journal.pone.0017487

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