A functional ABCA1 gene variant is associated with low HDL-cholesterol levels and shows evidence of positive selection in Native Americans.

doi:10.1093/hmg/ddq173

Article

A functional ABCA1 gene variant is associated with low HDL-cholesterol levels and shows evidence of positive selection in Native Americans.

Human molecular genetics - 15 Jul 2010

Acuña-Alonzo Víctor, Flores-Dorantes Teresa, Kruit Janine K, Villarreal-Molina Teresa, Arellano-Campos Olimpia, Hünemeier Tábita, Moreno-Estrada Andrés, Ortiz-López Ma Guadalupe, Villamil-Ramírez Hugo, León-Mimila Paola, Villalobos-Comparan Marisela, Jacobo-Albavera Leonor, Ramírez-Jiménez Salvador, Sikora Martin, Zhang Lin-Hua, Pape Terry D, Granados-Silvestre Ma de Angeles, Montufar-Robles Isela, Tito-Alvarez Ana M, Zurita-Salinas Camilo, Bustos-Arriaga José, Cedillo-Barrón Leticia, Gómez-Trejo Celta, Barquera-Lozano Rodrigo, Vieira-Filho Joao P, Granados Julio, Romero-Hidalgo Sandra, Huertas-Vázquez Adriana, González-Martín Antonio, Gorostiza Amaya, Bonatto Sandro L, Rodríguez-Cruz Maricela, Wang Li, Tusié-Luna Teresa, Aguilar-Salinas Carlos A, Lisker Ruben, Moises Regina S, Menjivar Marta, Salzano Francisco M, Knowler William C, Bortolini M Cátira, Hayden Michael R, Baier Leslie J, Canizales-Quinteros Samuel

Abstract excerpt

It has been suggested that the higher susceptibility of Hispanics to metabolic disease is related to their Native American heritage. A frequent cholesterol transporter ABCA1 (ATP-binding cassette transporter A1) gene variant (R230C, rs9282541) apparently exclusive to Native American individuals w...

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A functional ABCA1 gene variant is associated with low HDL-cholesterol levels and shows evidence of positive selection in Native Americans.

Abstract excerpt

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