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R230C but not - 565C/T variant of the ABCA1 gene is associated with type 2 diabetes in Mexicans through an effect on lowering HDL-cholesterol levels.

Journal of endocrinological investigation - 1 Aug 2020

Ochoa-Guzmán A, Moreno-Macías H, Guillén-Quintero D, Chávez-Talavera O, Ordoñez-Sánchez M L, Segura-Kato Y, Ortíz V, Díaz-Díaz E, Muñoz-Hernández L, García A, Pérez-Méndez O, Zentella-Dehesa A, Aguilar-Salinas C A, Tusié-Luna M T

Abstract excerpt

PURPOSE: Type 2 diabetes (T2D) and low serum concentration of high-density lipoprotein cholesterol (HDL-c) are common coexisting metabolic disorders. ABCA1 variants have been shown to be associated to these conditions. We sought to test the combined effect of two ABCA1 gene common variants, rs2422493 (- 565C > T) and rs9282541 (R230C) on HDL-c levels and T2D risk. METHODS: Path analysis was conducted in 3,303...

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Share to ATP Binding Cassette Transporter 1
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Share to Cholesterol, HDL
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PMID: 32016916
DOI: 10.1007/s40618-020-01187-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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