The ABCA1 gene R230C variant is associated with decreased risk of premature coronary artery disease: the genetics of atherosclerotic disease (GEA) study.

doi:10.1371/journal.pone.0049285

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The ABCA1 gene R230C variant is associated with decreased risk of premature coronary artery disease: the genetics of atherosclerotic disease (GEA) study.

PloS one - 1 Jan 2012

Villarreal-Molina Teresa, Posadas-Romero Carlos, Romero-Hidalgo Sandra, Antúnez-Argüelles Erika, Bautista-Grande Araceli, Vargas-Alarcón Gilberto, Kimura-Hayama Eric, Canizales-Quinteros Samuel, Juárez-Rojas Juan Gabriel, Posadas-Sánchez Rosalinda, Cardoso-Saldaña Guillermo, Medina-Urrutia Aída, González-Salazar María Del Carmen, Martínez-Alvarado Rocío, Jorge-Galarza Esteban, Carnevale Alessandra

Abstract excerpt

BACKGROUND: ABCA1 genetic variation is known to play a role in HDL-C levels and various studies have also implicated ABCA1 variation in cardiovascular risk. The functional ABCA1/R230C variant is frequent in the Mexican population and has been consistently associated with low HDL-C concentrations. Although it has been associated with other cardiovascular risk factors such as obesity and type 2 diabetes mellitus,...

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PMID: 23152888
DOI: 10.1371/journal.pone.0049285
PMCID: PMC3494680

Genes

ABCA1
CAD

Variants

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The ABCA1 gene R230C variant is associated with decreased risk of premature coronary artery disease: the genetics of atherosclerotic disease (GEA) study.PMID 23152888Read ↗

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