Article
The C-532T polymorphism of the angiotensinogen gene is associated with pulse pressure: a possible explanation for heterogeneity in genetic association studies of AGT and hypertension.
International journal of epidemiology - 1 Dec 2007
Baker Michelle, Rahman Thahira, Hall Darroch, Avery Peter J, Mayosi Bongani M, Connell John M C, Farrall Martin, Watkins Hugh, Keavney Bernard
Abstract excerpt
BACKGROUND: Many previous studies have investigated whether there is an association between genotypes at the angiotensinogen (AGT) gene and hypertensive status, but few have incorporated quantitative data. Although meta-analyses support a possible effect of AGT variants on blood pressure (BP), substantial unexplained between-study heterogeneity has been observed. We hypothesized that a primary effect of AGT...
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