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Article

P2Y12 polymorphisms and antiplatelet effects of aspirin in patients with coronary artery disease.

British journal of clinical pharmacology - 1 Apr 2008

Bierend Anneke, Rau Thomas, Maas Renke, Schwedhelm Edzard, Böger Rainer H

Abstract excerpt

WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT: * Genetic polymorphisms of the P2Y(12) ADP receptor on platelets have been shown to contribute to variability in platelet aggregation in healthy humans. * P2Y(12) ADP receptor polymorphisms are more frequently present in patients with vascular disease than in healthy people. * The majority of patients with vascular disease receive acetylsalicylic acid as an...

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Source

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Identifiers

PMID: 17995973
DOI: 10.1111/j.1365-2125.2007.03044.x
PMCID: PMC2291388

Genes

CAD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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P2Y12 polymorphisms and antiplatelet effects of aspirin in patients with coronary artery disease.PMID 17995973Read ↗

Adenosine diphosphate-induced platelet aggregation is associated with P2Y12 gene sequence variations in healthy subjects.Semantic proximity Read ↗

P2Y12 receptor gene polymorphism and antiplatelet effect of clopidogrel in patients with coronary artery disease after coronary stenting.Semantic proximity Read ↗

Pharmacogenetics of the antiplatelet effect of aspirin.Semantic proximity Read ↗

Ticagrelor yields consistent dose-dependent inhibition of ADP-induced platelet aggregation in patients with atherosclerotic disease regardless of genotypic variations in P2RY12, P2RY1, and ITGB3.Semantic proximity Read ↗

Adrenergic receptor polymorphisms and platelet reactivity after treatment with dual antiplatelet therapy with aspirin and clopidogrel in acute coronary syndrome.Semantic proximity Read ↗

Platelet function and antiplatelet therapy in cardiovascular disease: implications of genetic polymorphisms.Semantic proximity Read ↗

Influence of Genetic and Epigenetic Factors of P2Y12 Receptor on the Safety and Efficacy of Antiplatelet DrugsSemantic proximity Read ↗

[Genetic variants of platelet ADP receptor P2Y12 associated with changed platelet functional activity and development of cardiovascular diseases].Semantic proximity Read ↗

P2Y12 gene H2 haplotype is not associated with increased adenosine diphosphate-induced platelet aggregation after initiation of clopidogrel therapy with a high loading dose.Semantic proximity Read ↗

Gene sequence variations of the platelet P2Y12 receptor are associated with coronary artery disease.Semantic proximity Read ↗

Platelet reactivity and clopidogrel resistance are associated with the H2 haplotype of the P2Y12-ADP receptor gene.Semantic proximity Read ↗

P2RY12 gene polymorphisms and effect of clopidogrel on platelet aggregation.Semantic proximity Read ↗

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