Article
P2RY12 gene polymorphisms and effect of clopidogrel on platelet aggregation.
Collegium antropologicum - 1 Jun 2013
Galić Edvard, Vrbanić Luka, Kapitanović Sanja, Catela Ivković Tina, Petro Dubravka, Vuković Ivica, Bsharat Rebhi Sari, Milicević Zvonko, Vcev Aleksandar, Mirat Jure
Abstract excerpt
Objective of this study was to assess platelet response to clopidogrel and its association with certain single nucleotide polymorphisms (SNPs) of the P2RY12 gene. Several studies have shown that patients with poor in vitro response to clopidogrel have worse outcomes after coronary interventions. Pharmacological response to clopidogrel is mediated by the P2Y12 platelet receptor, therefore, SNPs of the P2RY12 gene...
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