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Article

Adenosine diphosphate-induced platelet aggregation is associated with P2Y12 gene sequence variations in healthy subjects.

Circulation - 26 Aug 2003

Fontana Pierre, Dupont Annabelle, Gandrille Sophie, Bachelot-Loza Christilla, Reny Jean-Luc, Aiach Martine, Gaussem Pascale

Abstract excerpt

BACKGROUND: The adenosine diphosphate (ADP) receptor P2Y12 plays a pivotal role in platelet aggregation, as demonstrated by the benefit conferred by its blockade in patients with cardiovascular disease. Some studies have shown interindividual differences in ADP-induced platelet aggregation responses ex vivo, but the mechanisms underlying this variability are unknown. METHODS AND RESULTS: We examined ADP-induced...

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PMID: 12912815
DOI: 10.1161/01.CIR.0000085073.69189.88

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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