Article
[Genetic variants of platelet ADP receptor P2Y12 associated with changed platelet functional activity and development of cardiovascular diseases].
Genetika - 1 Feb 2009
Sirotkina O V, Zabotina A M, Berkovich O A, Bazhenova E A, Vavilova T V, Shvartsman A L
Abstract excerpt
The key role in platelet aggregation is played by the platelet ADP receptor P2Y12, which is the target for antiaggregant drugs, clopidogrel and ticlopidine. At present, only sporadic data on genetic variants of platelet ADP receptor P2Y12 are available from literature, and their association with thromboembolic and cardiovascular diseases still remains obscure. Analysis of the group of subjects with high platelet...
Topics
- Adenosine Diphosphate
- Adult
- Alleles
- Amino Acid Substitution
- Blood Platelets
- Female
- Gene Frequency
- Humans
- Male
- Mutation, Missense
- Myocardial Infarction