Article
IRE1 signaling affects cell fate during the unfolded protein response.
Science (New York, N.Y.) - 9 Nov 2007
Lin Jonathan H, Li Han, Yasumura Douglas, Cohen Hannah R, Zhang Chao, Panning Barbara, Shokat Kevan M, Lavail Matthew M, Walter Peter
Abstract excerpt
Endoplasmic reticulum (ER) stress activates a set of signaling pathways, collectively termed the unfolded protein response (UPR). The three UPR branches (IRE1, PERK, and ATF6) promote cell survival by reducing misfolded protein levels. UPR signaling also promotes apoptotic cell death if ER stress is not alleviated. How the UPR integrates its cytoprotective and proapoptotic outputs to select between life or death...
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