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Diabetic retinopathy and Alzheimer's disease: Convergence of the unfolded protein response in neurodegeneration

1 Aug 2025

Abstract excerpt

Diabetic retinopathy (DR) and Alzheimer's disease (AD) are progressive neurodegenerative disorders affecting the eye and the brain, respectively. Despite targeting different organs, they share common molecular mechanisms. A central process connecting these conditions is the unfolded protein response (UPR), which maintains protein homeostasis in the endoplasmic reticulum (ER). Dysregulation of UPR pathways,...

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PMID: 40760071
DOI: 10.1002/alz.70497

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