Article
Resequencing of the human major histocompatibility complex in patients with rheumatoid arthritis and healthy controls in Alaska Natives of Southeast Alaska.
Tissue antigens - 1 Dec 2007
Yan Z, Ferucci E D, Geraghty D E, Yang Y, Lanier A P, Smith W P, Zhao L P, Hansen J A, Nelson J L
Abstract excerpt
High prevalence and severity of rheumatoid arthritis (RA) with an early age of onset have previously been described in Alaska Native and American Indian (AN/AI) populations. The contribution of HLA-DRB1 alleles encoding a similar amino acid sequence, referred to as the shared epitope (SE), to RA risk is well recognized in multiple populations worldwide. DRB1*1402 allele is the major SE-encoding allele in AN/AI...
Topics
- Alaska
- Arthritis, Rheumatoid
- Female
- Gene Frequency
- Genetic Predisposition to Disease
- Haplotypes
- Humans
- Immunity, Innate
- Indians, North American
- Major Histocompatibility Complex