Significance of DNA adducts at low dose: shortening the time to spontaneous tumor occurrence.

doi:10.1006/rtph.1996.0005

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Article

Significance of DNA adducts at low dose: shortening the time to spontaneous tumor occurrence.

Regulatory toxicology and pharmacology : RTP - 1 Feb 1996

Lutz W K, Gaylor D

Abstract excerpt

Formation and repair of adducts from DNA-reactive carcinogens as well as induction of genetic changes is expected to be proportional to dose as long as the rates of the enzymatic reactions are proportional to the substrate concentration and as long as the kinetics of cell division are not affecte...

Topics

Animals
Carcinogens
DNA Adducts
DNA Repair
Dose-Response Relationship, Drug
Humans
Incidence
Models, Theoretical
Mutation
Neoplasms
Risk Factors

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