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Concise review: managing genotoxicity in the therapeutic modification of stem cells.

Stem cells (Dayton, Ohio) - 1 Oct 2011

Baum Christopher, Modlich Ute, Göhring Gudrun, Schlegelberger Brigitte

Abstract excerpt

The therapeutic use of procedures for genetic stem cell modification is limited by potential adverse events related to uncontrolled mutagenesis. Prominent findings have been made in hematopoietic gene therapy, demonstrating the risk of clonal, potentially malignant outgrowth on the basis of mutations acquired during or after therapeutic genome modification. The incidence and the growth rate of insertional mutants...

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PMID: 21898683
DOI: 10.1002/stem.716

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