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Article

Sequence- and structure-specific determinants in the interaction between the RNA encapsidation signal and reverse transcriptase of avian hepatitis B viruses.

Journal of virology - 1 Jul 1997

Beck J, Nassal M

Abstract excerpt

Hepatitis B viruses (HBVs) replicate by reverse transcription of an RNA intermediate. Packaging of this RNA pregenome into nucleocapsids and replication initiation depend crucially on the interaction of the reverse transcriptase, P protein, with the cis-acting, 5' end-proximal encapsidation signal epsilon. The overall secondary structure is similar in all of the hepadnaviral epsilon signals, with a lower and an...

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Identifiers

PMID: 9188560
DOI: 10.1128/JVI.71.7.4971-4980.1997
PMCID: PMC191728

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Sequence- and structure-specific determinants in the interaction between the RNA encapsidation signal and reverse transcriptase of avian hepatitis B viruses.PMID 9188560Read ↗

Formation of a functional hepatitis B virus replication initiation complex involves a major structural alteration in the RNA template.Semantic proximity Read ↗

A pregenomic RNA sequence adjacent to DR1 and complementary to epsilon influences hepatitis B virus replication efficiency.Semantic proximity Read ↗

Few basepairing-independent motifs in the apical half of the avian HBV ε RNA stem-loop determine site-specific initiation of protein-priming.Semantic proximity Read ↗

A high level of mutation tolerance in the multifunctional sequence encoding the RNA encapsidation signal of an avian hepatitis B virus and slow evolution rate revealed by in vivo infection.Semantic proximity Read ↗

Hepatitis B virus replicationSemantic proximity Read ↗

Structure and function of the encapsidation signal of hepadnaviridae.Semantic proximity Read ↗

Evidence for multiple distinct interactions between hepatitis B virus P protein and its cognate RNA encapsidation signal during initiation of reverse transcription.Semantic proximity Read ↗

A bulged region of the hepatitis B virus RNA encapsidation signal contains the replication origin for discontinuous first-strand DNA synthesisSemantic proximity Read ↗

Mutations in the epsilon sequences of human hepatitis B virus affect both RNA encapsidation and reverse transcription.Semantic proximity Read ↗

The apical stem-loop of the hepatitis B virus encapsidation signal folds into a stable tri-loop with two underlying pyrimidine bulges.Semantic proximity Read ↗

Base Pairing between the 5′ Half of ε and a <i>cis</i> -Acting Sequence, Φ, Makes a Contribution to the Synthesis of Minus-Strand DNA for Human Hepatitis B VirusSemantic proximity Read ↗

dNTP versus NTP discrimination by phenylalanine 451 in duck hepatitis B virus P protein indicates a common structure of the dNTP-binding pocket with other reverse transcriptases.Semantic proximity Read ↗

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