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Article

Late effects of disturbed IGF signaling in congenital diseases.

Endocrine development - 1 Jan 2007

Cianfarani Stefano, Geremia Caterina, Puglianiello Antonella, Maiorana Arianna, Germani Daniela

Abstract excerpt

The biologic effects of insulin-like growth factor-1 (IGF-1) are mediated by specific cell surface receptors. IGF-1 binding to the extracellular alpha-subunits activates the tyrosine kinase intrinsic to the cytoplasmic portion of the IGF-1 receptor, leading to autophosphorylation of specific tyrosine residues in the receptor beta-subunit. One early molecular event that links the receptor kinase to the biologic...

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Identifiers

PMID: 17986823
DOI: 10.1159/000111054

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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