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Article

Role of third intracellular loop of the melanocortin 4 receptor in the regulation of constitutive activity.

Biochemical and biophysical research communications - 18 Jan 2008

Kim Do-Hun, Shin Seung Woo, Baik Ja-Hyun

Abstract excerpt

The melanocortin 4 receptor (MC4R) has been reported to display constitutive activity, which is probably relevant to the maintenance of a normal energy balance. Among the clinically reported mutants of MC4R in human obesity patients, we investigated the functional characteristics of seven mutants characterized by mutations in the third intracellular (i3) loop of MC4R. Via a CRE (cAMP responsive element)-mediated...

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PMID: 17986382
DOI: 10.1016/j.bbrc.2007.10.170

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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