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Article

The interaction of arginine- and tryptophan-rich cyclic hexapeptides with Escherichia coli membranes.

Journal of peptide science : an official publication of the European Peptide Society - 1 Apr 2008

Junkes Christof, Wessolowski Axel, Farnaud Sebastien, Evans Robert W, Good Liam, Bienert Michael, Dathe Margitta

Abstract excerpt

Cyclization of R- and W-rich hexapeptides has been found to enhance specifically the antimicrobial activity against Gram-negative Escherichia coli. To gain insight into the role of the bacterial outer membrane in mediating selectivity, we assayed the activity of cyclic hexapeptides derived from the parent sequence c-(RRWWRF) against several E. coli strains and Bacillus subtilis, L-form bacteria, and E. coli...

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Identifiers

PMID: 17985396
DOI: 10.1002/psc.940

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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