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Article

Analysis of in vitro activities and modes of action of synthetic antimicrobial peptides derived from an α-helical ‘sequence template’

3 Jan 2008

Abstract excerpt

OBJECTIVES: Cationic antimicrobial peptides (AMPs) are indispensable components of innate immune systems and promising candidates for novel anti-infective strategies. We rationally designed a series of peptides based on a template derived from known alpha-helical AMPs, which were then analysed regarding efficacy against clinical isolates and antibiotic mechanisms. METHODS: Efficacy tests included standard MIC and...

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PMID: 18174202
DOI: 10.1093/jac/dkm479

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