Article
Local structural constraints and charge distribution in the protegrin-1 arginine loop govern activity against colistin-resistant Klebsiella pneumoniae.
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy - 1 Jul 2026
DeBarro Christina, Assent Sofia, Makhecha Hannah, Krishnan Rakesh, Radde Noor, Randall Justin, de la Fuente-Nunez Cesar, Fleeman Renee M
Abstract excerpt
Carbapenem-resistant Klebsiella pneumoniae infections are increasingly treated with colistin as a last-resort antibiotic, but colistin resistance is rising, largely due to PhoPQ-mediated lipid A modifications. Host defense peptides (HDPs) and colistin are both cationic and amphipathic, yet HDPs are not uniformly affected by lipid A remodeling. To understand how certain HDPs can penetrate colistin-resistant...
Topics
- Klebsiella pneumoniae
- Drug Resistance, Bacterial
- Anti-Bacterial Agents
- Colistin
- Microbial Sensitivity Tests
- Antimicrobial Cationic Peptides
- Arginine
- Humans
- Mutation
- Klebsiella Infections
- Models, Molecular
- Lipid A