Investigating the mode of action of proline-rich antimicrobial peptides using a genetic approach: a tool to identify new bacterial targets amenable to the design of novel antibiotics.

Abstract excerpt

The proline-rich antimicrobial peptides (PRPs) are considered to act by crossing bacterial membranes without altering them and then binding to, and functionally modifying, one or more specific targets. This implies that they can be used as molecular hooks to identify the intracellular or membrane proteins that are involved in their mechanism of action and that may be subsequently used as targets for the design of...

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