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Article

Engineering of a stable retroviral gene delivery vector by directed evolution.

Molecular therapy : the journal of the American Society of Gene Therapy - 1 Feb 2008

Vu Halong N, Ramsey Joshua D, Pack Daniel W

Abstract excerpt

The lack of safe and effective delivery vectors continues to be a critical limitation facing human gene therapy. Viruses offer excellent efficiency but can be difficult and expensive to produce and purify. For example, the production and efficiency of murine leukemia virus (MLV) are limited by its inherent instability; the half-life of infectivity is 5-8 hours at 37 degrees C. In order to generate a stable MLV,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 17984974
DOI: 10.1038/sj.mt.6300350

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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