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Article

Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line.

Nucleic acids research - 25 Jun 1990

Morgenstern J P, Land H

Abstract excerpt

We report the development of an advanced system for transfer and expression of exogenous genes in mammalian cells based on Moloney murine leukemia virus (Mo MuLV). Extensive deletion/mutagenesis analysis to identify cis-acting signals involved in virus transmission has led to the design of a family of novel, highly efficient retroviral vectors and a partner helper-free packaging cell line. The pBabe retroviral...

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Identifiers

PMID: 2194165
DOI: 10.1093/nar/18.12.3587
PMCID: PMC331014

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