Article
Impact of novel human immunodeficiency virus type 1 reverse transcriptase mutations P119S and T165A on 4'-ethynylthymidine analog resistance profile.
Antimicrobial agents and chemotherapy - 1 Nov 2009
Yang Guangwei, Paintsil Elijah, Dutschman Ginger E, Grill Susan P, Wang Chuan-Jen, Wang Jimin, Tanaka Hiromichi, Hamasaki Takayuki, Baba Masanori, Cheng Yung-Chi
Abstract excerpt
2',3'-Didehydro-3'-deoxy-4'-ethynylthymidine (4'-Ed4T), a derivative of stavudine (d4T), has potent activity against human immunodeficiency virus and is much less inhibitory to mitochondrial DNA synthesis and cell growth than its progenitor, d4T. 4'-Ed4T triphosphate was a better reverse transcriptase (RT) inhibitor than d4T triphosphate, due to the additional binding of the 4'-ethynyl group at a presumed...
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