Article
Polymorphisms in eosinophil pathway genes, asthma and atopy.
Allergy - 1 Apr 2007
Kabesch M, Depner M, Dahmen I, Weiland S K, Vogelberg C, Niggemann B, Lau S, Illig T, Klopp N, Wahn U, Reinhardt D, von Mutius E, Nickel R
Abstract excerpt
BACKGROUND: Eosinophilic inflammation is considered to play an important role in the development as well as in the perpetuation of asthma. As eosinophil production and survival is under genetic control we investigated whether polymorphisms in eosinophil regulation pathway genes (IL-3, IL-5, GM-CSF and their respective enhancers and receptors) may influence the development of atopic diseases. METHODS: In two large...
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