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Article

CRISPR/Cas9-induced nos2b mutant zebrafish display behavioral abnormalities.

Genes, brain, and behavior - 1 Jun 2021

Gao Lei, Penglee Rachit, Huang Yajuan, Yi Xinxin, Wang Xiaojie, Liu Liping, Gong Xiaoling, Bao Baolong

Abstract excerpt

The immunomodulatory function of nitric oxide synthase (NOS2) has been extensively studied. However, some behavioral abnormalities caused by its mutations have been found in a few rodent studies, of which the molecular mechanism remains elusive. In this research, we generated nos2b gene knockout zebrafish (nos2bsou2/sou2 ) using CRISPR/Cas9 approach and investigated their behavioral and molecular changes by doing...

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PMID: 33200539
DOI: 10.1111/gbb.12716

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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