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Article

Monensin-resistant LLC-PK1 cell mutants are affected in recycling of the adenylate cyclase-stimulating vasopressin V2-receptor.

Molecular and cellular endocrinology - 1 Oct 1991

Jans D A, Jans P, Luzius H, Fahrenholz F

Abstract excerpt

The ionophore monensin was found to markedly reduce the rate of return of vasopressin V2-receptors to the membrane following down-regulation with [Arg8]vasopressin (AVP), as well as hormone dissociation (unloading) from cells following ligand binding and internalization in LLC-PK1 renal epithelial cells. Monensin-resistant LLC-PK1 mutants were isolated and characterized for V2-receptor recycling. Whilst the MN-41...

Topics

Adenylyl Cyclases
Animals
Arginine Vasopressin
Biological Transport
Cell Line
Cricetinae
Down-Regulation
Drug Resistance
Endocytosis
Ligands
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Monensin

Mutation

Receptors, Angiotensin

Receptors, Vasopressin

Source

Identifiers

PMID: 1797584
DOI: 10.1016/0303-7207(91)90215-e

Genes

AVP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1797584-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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