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Article

Functional role of the NPxxY motif in internalization of the type 2 vasopressin receptor in LLC-PK1 cells.

American journal of physiology. Cell physiology - 1 Oct 2003

Bouley Richard, Sun Tian-Xiao, Chenard Melissa, McLaughlin Margaret, McKee Mary, Lin Herbert Y, Brown Dennis, Ausiello Dennis A

Abstract excerpt

Interaction of the type 2 vasopressin receptor (V2R) with hormone causes desensitization and internalization. To study the role of the V2R NPxxY motif (which is involved in the clathrin-mediated endocytosis of several other receptors) in this process, we expressed FLAG-tagged wild-type V2R and a Y325F mutant V2R in LLC-PK1a epithelial cells that have low levels of endogenous V2R. Both proteins had a similar...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 12801889
DOI: 10.1152/ajpcell.00477.2002

Genes

AVP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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