Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Suppression of PTEN Expression Is Essential for Antiapoptosis and Cellular Transformation by Oncogenic Ras

1 Nov 2007

Abstract excerpt

Ras is one of the most commonly mutated oncogenes in the array of human cancers. The mechanism by which Ras induces cellular transformation is, however, not fully elucidated. We present here evidence that oncogenic Ras suppresses the expression of the tumor suppressor phosphatase and tensin homologue deleted from chromosome 10 (PTEN), and this action of oncogenic Ras is mediated by the Raf-mitogen-activated...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytokine Signaling Pathways and Interactions
Share to PI3K/AKT/mTOR signaling in cancer
Share to Protein Kinase Regulation and GTPase Signaling

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 17974977
DOI: 10.1158/0008-5472.can-07-1827

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Suppression of PTEN Expression Is Essential for Antiapoptosis and Cellular Transformation by Oncogenic RasPMID 17974977Read ↗

Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging.Semantic proximity Read ↗

Evidence that phosphatidylinositol 3-kinase- and mitogen-activated protein kinase kinase-4/c-Jun NH2-terminal kinase-dependent Pathways cooperate to maintain lung cancer cell survival.Semantic proximity Read ↗

PAK signaling in cancerSemantic proximity Read ↗

Tumor suppressor PTEN: modulator of cell signaling, growth, migration and apoptosisSemantic proximity Read ↗

PTEN: its deregulation and tumorigenesis.Semantic proximity Read ↗

The p38 pathway provides negative feedback for Ras proliferative signaling.Semantic proximity Read ↗

Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis.Semantic proximity Read ↗

Role of JNK in Tumor DevelopmentSemantic proximity Read ↗

Biological role of phosphatase PTEN in cancer and tissue injury healing.Semantic proximity Read ↗

Tenets of PTEN tumor suppression.Semantic proximity Read ↗

The serine/threonine kinase PAK4 prevents caspase activation and protects cells from apoptosis.Semantic proximity Read ↗

PTEN signaling pathways in melanoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.