Article
Characterization of murine S-endoglin isoform and its effects on tumor development.
Oncogene - 23 Jun 2005
Pérez-Gómez Eduardo, Eleno Nélida, López-Novoa Jose Miguel, Ramirez Jose Ramón, Velasco Beatriz, Letarte Michelle, Bernabéu Carmelo, Quintanilla Miguel
Abstract excerpt
Endoglin is a transmembrane glycoprotein that acts as an auxiliary receptor for transforming growth factor-beta (TGF-beta) and modulates cellular responses to this pleiotropic cytokine. Endoglin is strongly expressed in endothelial cells, where it appears to exert a crucial role in vascular development and angiogenesis. Two endoglin isoforms (L and S), differing in their cytoplasmic domains, have been previously...
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