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Loss of the p53/p63 Regulated Desmosomal Protein Perp Promotes Tumorigenesis

21 Oct 2010

Abstract excerpt

Dysregulated cell-cell adhesion plays a critical role in epithelial cancer development. Studies of human and mouse cancers have indicated that loss of adhesion complexes known as adherens junctions contributes to tumor progression and metastasis. In contrast, little is known regarding the role of the related cell-cell adhesion junction, the desmosome, during cancer development. Studies analyzing expression of...

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PMID: 20975948
DOI: 10.1371/journal.pgen.1001168

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