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Article

Global disruption of cell cycle progression and nutrient response by the antifungal agent amiodarone.

The Journal of biological chemistry - 28 Dec 2007

Zhang Yong-Qiang, Rao Rajini

Abstract excerpt

The antiarrhythmic drug amiodarone has fungicidal activity against a broad range of fungi. In Saccharomyces cerevisiae, it elicits an immediate influx of Ca(2+) followed by mitochondrial fragmentation and eventual cell death. To dissect the mechanism of its toxicity, we assessed the transcriptional response of S. cerevisiae to amiodarone by DNA microarray. Consistent with the drug-induced calcium burst, more than...

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Identifiers

PMID: 17974566
DOI: 10.1074/jbc.M707593200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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