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Article

Antifungal activity of amiodarone is mediated by disruption of calcium homeostasis.

The Journal of biological chemistry - 1 Aug 2003

Gupta Soma Sen, Ton Van-Khue, Beaudry Veronica, Rulli Samuel, Cunningham Kyle, Rao Rajini

Abstract excerpt

The antiarrhythmic drug amiodarone was recently demonstrated to have novel broad range fungicidal activity. We provide evidence that amiodarone toxicity is mediated by disruption of Ca2+ homeostasis in Saccharomyces cerevisiae. In mutants lacking calcineurin and various Ca2+ transporters, including pumps (Pmr1 and Pmc1), channels (Cch1/Mid1 and Yvc1), and exchangers (Vcx1), amiodarone sensitivity correlates with...

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Identifiers

PMID: 12754197
DOI: 10.1074/jbc.M303300200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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