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Article

Cch1p mediates Ca2+ influx to protect Saccharomyces cerevisiae against eugenol toxicity.

PloS one - 1 Jan 2012

Roberts Stephen K, McAinsh Martin, Widdicks Lisa

Abstract excerpt

Eugenol has antifungal activity and is recognised as having therapeutic potential. However, little is known of the cellular basis of its antifungal activity and a better understanding of eugenol tolerance should lead to better exploitation of eugenol in antifungal therapies. The model yeast, Saccharomyces cerevisiae, expressing apoaequorin was used to show that eugenol induces cytosolic Ca(2+) elevations. We...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23028482
DOI: 10.1371/journal.pone.0043989
PMCID: PMC3441571

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