Article

When and why an essential popular mineral—calcium—is an effective antifungal adjuvant against the human pathogen?

2020-08-24

Abstract excerpt

In eukaryotes, calcium not only is an essential mineral nutrient but also serves as an intracellular second messenger that is necessary for many physiological processes. Here, we show that exogenous calcium is toxic when fungal cells lack functional calcineurin, a calcium-dependent protein phosphatase that acts as the central regulator of the calcium signaling pathway. By monitoring intracellular calcium, particul...

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Literature Corpus work: 37fd1fc6-b0e1-5534-b318-e74a6d26e3ef
DOI: 10.1101/2020.08.23.263939

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