Essential role of calcineurin in response to endoplasmic reticulum stress.

doi:10.1093/emboj/21.10.2343

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Article

Essential role of calcineurin in response to endoplasmic reticulum stress.

The EMBO journal - 15 May 2002

Bonilla Myriam, Nastase Kristin K, Cunningham Kyle W

Abstract excerpt

Depletion of calcium ions (Ca2+) from the endoplasmic reticulum (ER) of yeast cells resulted in the activation of the unfolded protein response (UPR) signaling pathway involving Ire1p and Hac1p. The depleted ER also stimulated Ca2+ influx at the plasma membrane through the Cch1p-Mid1p Ca2+ channel and another system. Surprisingly, both Ca2+ influx systems were stimulated upon accumulation of misfolded proteins in...

Topics

Antifungal Agents
Blotting, Northern
Calcineurin
Calcium Channels
Calcium Signaling
Calmodulin
Cell Membrane
Cell Survival
DNA, Fungal
Endoplasmic Reticulum
Genotype
Polymerase Chain Reaction
Protein Folding
Saccharomyces cerevisiae
Signal Transduction
Stress, Mechanical
Tunicamycin

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PMID: 12006487
DOI: 10.1093/emboj/21.10.2343
PMCID: PMC126012

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