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Article

Essential role of calcineurin in response to endoplasmic reticulum stress.

The EMBO journal - 15 May 2002

Bonilla Myriam, Nastase Kristin K, Cunningham Kyle W

Abstract excerpt

Depletion of calcium ions (Ca2+) from the endoplasmic reticulum (ER) of yeast cells resulted in the activation of the unfolded protein response (UPR) signaling pathway involving Ire1p and Hac1p. The depleted ER also stimulated Ca2+ influx at the plasma membrane through the Cch1p-Mid1p Ca2+ channel and another system. Surprisingly, both Ca2+ influx systems were stimulated upon accumulation of misfolded proteins in...

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Identifiers

PMID: 12006487
DOI: 10.1093/emboj/21.10.2343
PMCID: PMC126012

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CCS

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Source receipt: pubmed, retrieved 7 Sept 2026.

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