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Human CD3 Transgenic Mice: Preclinical Testing of Antibodies Promoting Immune Tolerance

2 Feb 2011

Abstract excerpt

Monoclonal antibodies have proven to be potent agents to promote immunological tolerance in animal models of autoimmune disease and transplantation. However, optimal clinical application and pharmaceutical development have been limited by the species specificity of therapeutic antibodies, as well exemplified in the case of anti-CD3 antibodies. Compelling evidence in the nonobese diabetic (NOD) mouse, recently...

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PMID: 21289272
DOI: 10.1126/scitranslmed.3001830

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