A conserved CaM- and radial spoke associated complex mediates regulation of flagellar dynein activity.

Abstract excerpt

For virtually all cilia and eukaryotic flagella, the second messengers calcium and cyclic adenosine monophosphate are implicated in modulating dynein- driven microtubule sliding to regulate beating. Calmodulin (CaM) localizes to the axoneme and is a key calcium sensor involved in regulating motility. Using immunoprecipitation and mass spectrometry, we identify members of a CaM-containing complex that are involved...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Axoneme
• Share to Calmodulin
• Share to Chlamydomonas reinhardtii