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Article

Building blocks of the nexin-dynein regulatory complex in Chlamydomonas flagella.

The Journal of biological chemistry - 19 Aug 2011

Lin Jianfeng, Tritschler Douglas, Song Kangkang, Barber Cynthia F, Cobb Jennifer S, Porter Mary E, Nicastro Daniela

Abstract excerpt

The directional flow generated by motile cilia and flagella is critical for many processes, including human development and organ function. Normal beating requires the control and coordination of thousands of dynein motors, and the nexin-dynein regulatory complex (N-DRC) has been identified as an important regulatory node for orchestrating dynein activity. The nexin link appears to be critical for the...

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Identifiers

PMID: 21700706
DOI: 10.1074/jbc.M111.241760
PMCID: PMC3190725

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Building blocks of the nexin-dynein regulatory complex in Chlamydomonas flagella.PMID 21700706Read ↗

The dynein regulatory complex is the nexin link and a major regulatory node in cilia and flagella.Semantic proximity Read ↗

DRC2/CCDC65 is a central hub for assembly of the nexin-dynein regulatory complex and other regulators of ciliary and flagellar motility.Semantic proximity Read ↗

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A unified taxonomy for ciliary dyneins.Semantic proximity Read ↗

Scaffold subunits support associated subunit assembly in the <i>Chlamydomonas</i> ciliary nexin-dynein regulatory complexSemantic proximity Read ↗

Detailed structural and biochemical characterization of the nexin-dynein regulatory complex.Semantic proximity Read ↗

Consensus nomenclature for dyneins and associated assembly factors.Semantic proximity Read ↗

Cryoelectron tomography reveals doublet-specific structures and unique interactions in the I1 dynein.Semantic proximity Read ↗

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A subunit of the dynein regulatory complex in Chlamydomonas is a homologue of a growth arrest-specific gene product.Semantic proximity Read ↗

Functional diversity of axonemal dyneins as assessed by in vitro and in vivo motility assays of Chlamydomonas mutants.Semantic proximity Read ↗

The nexin-dynein regulatory complex subunit DRC1 is essential for motile cilia function in algae and humans.Semantic proximity Read ↗

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