Article
Effect of structural modifications of ganglioside GM2 on intra-molecular carbohydrate-to-carbohydrate interaction and enzymatic susceptibility.
Biochimica et biophysica acta - 1 Mar 2008
Li Yu-Teh, Li Su-Chen, Kiso Makoto, Ishida Hideharu, Mauri Laura, Raimondi Laura, Bernardi Anna, Sonnino Sandro
Abstract excerpt
The effect of inter-molecular carbohydrate-to-carbohydrate interaction on basic cell biological processes has been well documented and appreciated. In contrast, very little is known about the intra-molecular carbohydrate-to-carbohydrate interaction. The presence of an interaction between the GalNAc and the Neu5Ac in GM2 detected by NMR spectroscopy represents a well-defined intra-molecular...
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