Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Synthesis of novel NBD-GM1 and NBD-GM2 for the transfer activity of GM2-activator protein by a FRET-based assay system.

Glycobiology - 1 Dec 2005

Schwarzmann Günter, Wendeler Michaela, Sandhoff Konrad

Abstract excerpt

The ganglioside-activator protein is an essential cofactor for the lysosomal degradation of ganglioside GM2 (GM2) by beta-hexosaminidase A. It mediates the interaction between the water-soluble exohydrolase and its membrane-embedded glycolipid substrate at the lipid-water interphase. Mutations in the gene encoding this glycoprotein result in a fatal neurological storage disorder, the AB variant of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to beta-N-Acetylhexosaminidases
Share to Chromatography, Thin Layer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to G(M1) Ganglioside

Share to G(M2) Ganglioside

Share to Gangliosides

Share to Glycolipids

Share to Sphingolipids

Share to Tay-Sachs Disease

Source

Identifiers

PMID: 16079415
DOI: 10.1093/glycob/cwj018

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Synthesis of novel NBD-GM1 and NBD-GM2 for the transfer activity of GM2-activator protein by a FRET-based assay system.PMID 16079415Read ↗

The GM2 gangliosidoses: Unlocking the mysteries of pathogenesis and treatment.Semantic proximity Read ↗

Heterocyclic sterol probes for live monitoring of sterol trafficking and lysosomal storage disordersSemantic proximity Read ↗

Human Saposin B Ligand Binding and Presentation to α-Galactosidase ASemantic proximity Read ↗

A Dual Fluorescent-Raman Bioorthogonal Probe for Specific Biosynthetic Labeling of GangliosidesSemantic proximity Read ↗

Revealing the Activity of Trimeric G-proteins in Live Cells with a Versatile Biosensor Design.Semantic proximity Read ↗

BRED: bioluminescence energy transfer to dye for monitoring ceramide trafficking in cellSemantic proximity Read ↗

Expression of recombinant human GM2-activator protein in insect cells: purification and characterization by mass spectrometry.Semantic proximity Read ↗

Rare Variant of GM2 Gangliosidosis through Activator-Protein Deficiency.Semantic proximity Read ↗

The GM2-gangliosidoses and the elucidation of the beta-hexosaminidase system.Semantic proximity Read ↗

GLTP mediated non-vesicular GM1 transport between native membranes.Semantic proximity Read ↗

Intracellular degradation of sulforhodamine-GM1: use for a fluorescence-based characterization of GM2-gangliosidosis variants in fibroblasts and white blood cells.Semantic proximity Read ↗

The competitor-introduced Ggamma recruitment system, a new approach for screening affinity-enhanced proteins.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.