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Improvement of interferon-γ sialylation in Chinese hamster ovary cell culture by feeding ofN-acetylmannosamine

20 Jun 1998

Abstract excerpt

Because the presence of sialic acid can extend circulatory lifetime, a high degree of sialylation is often a desirable feature of therapeutic glycoproteins. In this study, the incomplete intracellular sialylation of interferon-gamma (IFN-gamma), produced by Chinese hamster ovary cell culture, was minimized by supplementing the culture medium with N-acetylmannosamine (ManNAc), a direct intracellular precursor for...

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PMID: 10099302
DOI: 10.1002/(sici)1097-0290(19980620)58:6<642::aid-bit10>3.0.co;2-9

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