Classification of disorders of GM2 ganglioside hydrolysis using 3H-GM2 as substrate.

doi:10.1016/0304-4165(94)90118-x

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Article

Classification of disorders of GM2 ganglioside hydrolysis using 3H-GM2 as substrate.

Biochimica et biophysica acta - 2 Mar 1994

Novak A, Callahan J W, Lowden J A

Abstract excerpt

Rates of GM2 ganglioside hydrolysis by fibroblasts from normal controls and patients with GM2 gangliosidosis were measured in situ, with cells growing in tissue culture by assaying the decrease in cell-incorporated 3H-GM2 over time, and in vitro by assaying the rate of 3H-GM2 hydrolysis using fib...

Topics

Carbohydrate Sequence
Cell Line
Culture Media
Fibroblasts
G(M2) Ganglioside
Half-Life
Humans
Hydrolysis
Infant, Newborn
Isoenzymes
Molecular Sequence Data
Mutation
Radioactivity
Sandhoff Disease
Taurocholic Acid
Tay-Sachs Disease
beta-N-Acetylhexosaminidases

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